Mounjaro Pharmacology

Tirzepatide (Mounjaro) is an imbalanced and biased dual GIP and GLP-1 receptor agonist Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist which appears more active towards GIP than GLP-1, which may have beneficial implications. “Tirzepatide selectively engages cAMP signaling over β-arrestin recruitment at the GLP-1R may be of fundamental importance thatContinueContinue reading “Mounjaro Pharmacology”

In case you had any doubts about climate change🤔

Pakistan is experiencing an unprecedented humanitarian crisis with more than a third of the country under flood water, affecting 33 million people (15% of the population), says the UN. “The Pakistani people are facing a monsoon on steroids; the relentless impact of epochal levels of rain and flooding,” said António Guterres, UN Secretary-General, in aContinueContinue reading “In case you had any doubts about climate change🤔”

Reading a good book — Profound

“When all thermonuclear sources of energy are exhausted a sufficiently heavy star will collapse. Unless it reduces its mass due to fission, rotation or radiation, this contraction will continue indefinitely,” forming the black hole that Schwarzschild had prophesied, capable of crumpling space like a piece of paper and extinguishing time like a blown-out candle, andContinueContinue reading “Reading a good book — Profound”

Guns in Delaware

Delaware Gun Legislation Passed • HB450 Assault Rifle Ban • HB451 Raises Age 18 to 21, shotgun exception • HB423 Background Checks • SB1subSB6 High Capacity Magazine (>17) • SB302 Gun manufacturer liability • SB8 Bump stocks https://news.delaware.gov/2022/06/30/governor-carney-signs-package-of-gun-safety-legislation/ Recent Federal Gun Legislation • Red Flag Laws ($750 million to states) • Closed boyfriend loophole •ContinueContinue reading “Guns in Delaware”

The Matter with Things Chapter 1

Some PreliminariesProcesses within the brain that oppose other processes (inhibition) are important in control of brain funtion.”the proper working of the body depends on what he called ‘opponent processors’, systems that complement and counterbalance one another by their essentially opposing actions””In the brain there are three main such pairs of opponent processors, ranged along eachContinueContinue reading “The Matter with Things Chapter 1”

My Favorite Macs (for now)

Apple has released some phenomenal Mac computers, featuring the M1 and M2 processors. They have a great comparison page where I have listed my 3 favorites. The MacBook Air is probably the best choice for most people. It has phenomenal battery life (up to 15 hours!) and a very fast M2 processor, which blows IntelContinueContinue reading “My Favorite Macs (for now)”