glymphatic – Dr Bob, Brain Mechanic

The Evidence Gap in Deep Cervical Lymphatic Procedures for Alzheimer’s

Deep cervical lymphatic-venous anastomosis is one of the more interesting failures-in-progress in recent Alzheimer’s research. Theoretically seductive, evidentially threadbare, and already the subject of a regulatory ban in the country where it originated. The theoretical case The rationale rests on the glymphatic–meningeal lymphatic clearance model: cerebrospinal and interstitial fluid carry metabolic waste, including amyloid-β andContinueContinue reading “The Evidence Gap in Deep Cervical Lymphatic Procedures for Alzheimer’s”

Sleep is good, may prevent dementia

How the brain gets rid of its chemical waste through the glymphatics during sleep, via blood vessel oscillations, regulated by norepinephrine. Impeded by Ambien. • Norepinephrine release from the locus coeruleus drives slow vasomotion in NREM sleep • Infraslow norepinephrine oscillations control opposing changes in blood and CSF volumes • Norepinephrine oscillation frequency during NREMContinueContinue reading “Sleep is good, may prevent dementia”